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  • Inflam-D 200mg 400 mg dexibuprofen tablet | Andmedicine.com

    Inflam-D
    [Since 19931
    Presentation
    Inflam-D 200 tablet: White, hexagonal, film coated tablet; each
    tablet contains Dexibuprofen INN 200mg.a
    Inflam-D 300 tablet: White, hexagonal, film coated tablet; each
    tablet contains Dexibuprofen INN 300 mg.
    Inflam-D 400 tablet: White, hexagonal, film coated tablet; each
    tablet contains Dexibuprofen INN 400 mg.
    Pharmacokinctks
    Dexibuprofen is absorbed primarily from the small intestine. After metabolic transformation in the liver (hydroxylation, carboxylation) the pharmacologically inactive metabolites are completely excreted, mainly by the kidneys (90%), but also in the bile. The elimination half-life is 1.8 • 3.5 hours; the plasma protein binding is about 99% Maximum plasma levels are reached about 2 hours after oral administration
    The administration of dexibuprofen with a meal delays the lime to reach maximum concentrations (from 2.1 hours after fasting conditions to 2.8 hours after non-fasting conditions) and decreases the maximum plasma concentrations (from 20.6 to 18.1 ug/ml. which is of no clinical relevance), but has no effect on the extent of absorption
    Indication
    Dexibuprofen is recommended for pain and inflammation associated with osteoarthritis and other musculoskeletal disorders It is also used to relieve mild to moderate pairi and inflammation including dysmenorrhoea. dental pain and period pain
    Dose and Administration
    For the treatment of mild to moderate pain, initially single doses of 200 mg dexibuprofen and daily doses of 600 mg dexibuprofen are recommended. The maximum single dose is 400 mg dexibuprofen.
    For dysmenorrhoea a daily dose of 600 to 900 mg dexibuprofen, divided in up to three single doses, is recommended. The maximum single dose is 300 mg; the maximum daily dose is 900 mg.
    Contra-indication
    Dexibuprofen must not be administered in the following cases:
    - Patients previously sensitive to dexibuprofen, to any other NSAID that cause precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema
    - Patients who have gastrointestinal bleeding or other active bleedings or bleeding disorders, active Crohn’s disease or active ulcerative colitis, severe heart failure, severe renal dysfunction (GFR < 30ml/min). severely impaired hepatic function, hemorrhagic diathesis and other coagulation disorders, or patients receiving anticoagulant therapy.
    - In pregnant mother from the beginning of 6th month of pregnancy
    Medicines and their possible side effects can affect individual
    people in different ways.
    - Disturbances of the gut such as nausea, vomiting, diarrhoea, indigestion or abdominal pain, bleeding from the stomach or intestine
    - Headache, dizziness, drowsiness, confusion, depression, visual disturbances
    - Balance disorders involving the inner ear (vertigo), sensation of ringing or noise in the ears (tinnitus)
    Retention of water in the body tissues (fluid retention), resulting in swelling (oedema) ultimately kidney, liver or blood disorders
    • Abnormal reaction of the skin to light, usually a rash, allergic reactions such as severe skin rashes, swelling of the lips and photosensitivity
    Precautions
    Dexibuprofen has not been studied in children and adolescents
    (< 18 years). Safety and efficacy have not been established and
    therefore it is not recommended in these age groups.
    In elderly patients it is recommended to start the therapy at the
    lower end of the dosage range. The dosage may be increased to
    that recommended for general population only after good
    general tolerance has been ascertained.
    Like other NSAIDs, dexibuprofen should be taken with”food to
    reduce gastrointestinal irritation, particularly during chronic
    use.
    Pregnancy and Lactation
    This medicine should not be used in the third trimester of pregnancy, as it may delay labour, increase the length of labour and cause complications in the newborn baby. It should only be used in the first and second trimesters if the potential benefit outweighs any potential risk to the foetus.
    Some evidence suggests that women attempting to conceive should also avoid NSAIDs as they may temporarily reduce female fertility during treatment and may also increase the risk of miscarriage or malformations
    medicine may pass into breast milk, but in such small quantities that it is unlikely to harm the baby if the dose is low and treatment is short.
    Drug Interactions
    Dexibuprofen should not be taken in combination with
    painkilling doses of aspirin or any other oral NSAID, e.g.,
    ibuprofen. as this increases the risk of side effects on the
    stomach and intestines. Selective inhibitors of COX-2 such as
    celecoxib or etoricoxib should also be avoided for the same
    reason.
    Dexibuprofen cause an increased risk of bleeding from the gut if is taken with:
    - anti-blood-clotting (anticoagulant) medicines such as warfarin
    - antiplatelet medicines to reduce the risk of blood cjots or ‘thin the blood’, e.g., low-dose aspirin, dipyridamole, clopidogrel.
    - SSRI antidepressants, eg fluoxetine. paroxetine, citalopram, venlafaxine.
    Risk of side effects on the kidneys is increased if is taken with: ACE inhibitors, e.g.,
    enalapril; angiotensin II antagonists, e.g., losartan; ciclosporin diuretics, e.g.. furosemide; tacrolimus.
    Dexibuprofen may reduce the removal of digoxin. lithium, methotrexate from the body and so may increase the blood levels and risk of side effects of these medicines:
    Dexibuprofen may oppose the blood pressure lowering effects of certain medicines such as amlodipine, ACE inhibitors, and beta-blockers to treat high blood pressure.
    Storage Condition
    Store in a cool and dry place, protect from light. Don’t store
    above 25°C
    Commercial Pack
    Inflam-D 200 tablet: Box of 10 x 10 in alu-PVC blister pack. Inflam-D 300 tablet: Box of 10 x 10 in alu-PVC blister pack. Inflam-D 400 tablet: Box of 5 x 10 in alu-PVC blister pack.

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