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  • Mebendazole – Andmedicine.com

    Description
    Mebendazole is a synthetic broad-spectrum anthelmintic that is active against most nematodes and some other worms. Mebendazole is principally used in the treatment of intestinal nematode infection.
    Mode of action
    Mebendazole inhibits the formation of the worms’ microtubules and causes the worms’ glucose depletion.
    Pharmacokinetics
    After oral administration about 2-10% of oral dose is absorbed from Gl tract and peak plasma concentration occurs within 0.5 to 7 hours. Mebendazole is highly bound to plasma protein. Elimination half-life is 2.8 to 9 hours.
    Composition
    mebendazole 100 mg Tablet: Each tablet contains
    Mebendazole USP 100 mg.
    Solas® Suspension: Each 5 ml contains
    Mebendazole USP 100 mg.
    Indications
    Mebendazole is indicated for the treatment of threadworms, whipworms, roundworms and hookworms.
    Dosage & administration
    Adult and Child over 2 years
    Worm Dose Frequency & Duration
    Threadworms 100 mg or 1 teaspoonful Single dose*
    Whipworms 1 00 mg or 1 teaspoonful Twice daily for 3 days
    Roundworms
    Hookworms
    * if reinfection occurs second dose may be needed
    after 2 weeks.
    Child under 2 years is not recommended.
    Contraindications
    Mebendazole is contraindicated in persons who have shown hypersensitivity to the drug.
    Side effects
    Gastrointestinal: Transient symptoms of abdominal pain and diarrhoea in case of massive infection and expulsion of worms. Hypersensitivity: Rash, urticaria and angioedema have been observed on
    re occasions. Central Nervous System: Very rare cases of convulsions have been reported. Haematologic: Neutropenia and agranuiocytosis.
    Use in pregnancy & Jactation
    Mebendazole is not recommended in pregnant women. It is not known whether mebendazole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when it is administered to a nursing mother.
    Precautions
    General: Periodic assessment of organ system functions, including haematopoietic and hepatic, is advisable during prolonged therapy. Paediatric use: The drug has not been extensively studied in children under two years; therefore, in the treatment of children under two years the relative benefit/risk should be considered. Information for Patients: Patients should be informed of the potential risk to the foetus in women taking mebendazole during pregnancy, especially during the first trimester. Patients should also be informed that cleanliness is important to prevent reinfection & transmission of the infection.
    Drug interactions
    Preliminary evidence suggests that cimetidine inhibits mebendazole metabolism and may result in an increase in plasma concentration.
    Overdosage
    In the event of accidental overdosage gastrointestinal complaints lasting up to a few hours may occur. Vomiting and purging should be induced.
    Storage
    Store in a cool and dry place, protected from light.
    Packaging
    Mebendazole 100 mg Tablet: Each carton contains 6×10 tablets in blister pack.
    Mebendazole Suspension: Each carton contains a bottle having 30 ml suspension

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